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Fibrates and thiazolidinediones are agonists of peroxisome proliferator-activated receptors (PPAR) α and γ, pharmacologically designed to control dyslipidemia and insulin resistance, respectively. Several works have reported the toxicity of some agonists in a number of tissues. In this work we have analyzed the toxicity of two PPARα (WY14643 and clofibrate) and two PPARγ (pioglitazone and ciglitazone)...
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