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We propose an effect size based approach to compute initial dissimilarities for Ensemble Algorithm of Clustering Cancer Data (EACCD). The proposed method is applied to the colon cancer data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute and compared with the log-rank approach where initial dissimilarities are computed from the log-rank test statistic...
We propose a hierarchical clustering method for prognostic clustering of cancer patients. Dissimilarity between two subsets of patients is defined as the area between two corresponding Kaplan-Meier curves. The proposed method is applied to the breast cancer data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute and compared with the linkage approach...
The TNM staging system is universally used for classification of cancer. This system is limited since it uses only three factors (tumor size, extent of spread to lymph nodes, and status of distant metastasis) to generate stage groups. To provide a more accurate description of cancer and thus better patient care, additional factors or variables should be used to classify cancer. In this paper we propose...
Though the TNM (Tumor, Lymph Node, Metastasis) is a widely used staging system for predicting the outcome of cancer patients, it is limited in prediction mainly because it does not integrate multiple prognostic factors. Expanding the TNM now becomes possible due to availability of large cancer patient datasets. In this paper, we introduce a group testing algorithm that can be used to add new prognostic...
Accurate prediction of survival rates of cancer patients is often key to stratify patients for prognosis and treatment. Survival prediction is often accomplished by the TNM system that involves only three factors: tumor extent, lymph node involvement, and metastasis. This prediction from the TNM has been limited, mainly because other potential prognostic factors are not used in the system. Based on...
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