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Mitotic centromere–associated kinesin (MCAK) is a microtubule depolymerase indispensable for microtubule binding during spindle formation. The purpose of this study was to investigate the association of MCAK expression with squamous cell carcinoma of the oral tongue (SCCOT).Immunohistochemistry was used in 47 cases of SCCOT. Determination of proliferation and migratory capabilities was performed with...
Squamous cell carcinoma of the oral tongue (SCCOT) is one of the most common malignant carcinomas in the head and neck. Recurrence and/or metastasis often results in failure of treatment and decreases the survival of the patients. The purpose of this study is to investigate the effect of gene-silence of Kif2a on SCCOT in viro and in vivo.Plasmid-mediated expression of Kif2a-siRNA (pGPU6/GFP/Kif2a)...
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