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Malaria is a serious infectious disease that affects 300–500 million people in the world. The proteins involved in heat shock response in the malaria parasite Plasmodium falciparum have long been considered as promising vaccine and drug targets. Our comprehensive network analysis reveals that about 103 heat shock proteins are associated with over 900 other proteins. They may play roles in a wide variety...
Sigma factors play important roles in transcriptional regulation in bacteria. Streptomyces coelicolor, a soil bacterium which is best known for its production of a variety of antibiotics, possesses a sophisticated transcriptional machinery. Among 58 sigma factors identified in the genome, 44 are extra-cytoplasmic function (ECF) sigma factors, which coordinate cellular responses to external signals...
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