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Both prostaglandin A 1 (PGA 1 ) and lithium have been reported to protect neurons against excitotoxic and ischemic injury. The present study was undertaken to examine the effects of lithium and PGA1 on heat shock proteins (HSP) and the growth arrest and DNA-damage-inducible gene (GADD153) and to evaluate if lithium could potentiate PGA 1 's neuroprotective effects against cerebral...
The present study evaluated the neuroprotective potential of prostaglandin A 1 (PGA 1 ) in rodent models of focal cerebral ischemia. PGA 1 33 nmol reduced infarction volume by about 43% (P < 0.05) when administered intracerebroventricularly before and after transient ischemia in mice. PGA 1 16.5–66 nmol diminished infarction volume by 18% to 27% (P < 0.01) when...
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