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Cardiac actin (ACTC) is the fetal homologue of skeletal muscle actin (ACTA1), and is switched off at birth in skeletal muscle but remains highly expressed in adult heart and in regenerating muscle. ACTC is 99% identical to ACTA1 protein, differing at only 4 amino acids. We previously showed an ACTC transgene could functionally replace ACTA1 in postnatal skeletal muscle of Acta1 knockout mice that...
Analysis of voluntary running wheel activity in mice is a useful phenotypic measure of skeletal muscle function. We have collected voluntary running wheel activity and total body weight data from >50 strains of mice belonging to the ‘Collaborative Cross’ (aka The Gene Mine), and compared these to known models of neuromuscular disease. The Gene Mine is a mouse reference population derived from eight...
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