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A high-resolution PDMS-based conformable microelectrode array (cMEA) with integrated electronics is implemented. The cMEA is incorporated into individual layers of a nanofiber-based nerve regeneration scaffold to create a novel regenerative electrode scaffold (RES) capable of establishing a stable, high-resolution peripheral nerve interface. The device features a compact size with an enhanced signal-to-noise...
A method for fabricating polydimethylsiloxane (PDMS) based microelectrode arrays (MEAs) featuring novel conical-well microelectrodes is described. The fabrication technique is reliable and efficient, and facilitates controllability over both the depth and the slope of the conical wells. Because of the high-PDMS elasticity (as compared to other MEA substrate materials), this type of compliant MEA is...
With our recent advances in polydimethylsiloxane (PDMS) based conformable microelectrode array (MEA) technologies, numerous exciting prosthetic applications involving neural/muscular surface recording and/or stimulation techniques become more accessible. As a pilot investigation, in this paper, we explore the general concept of recording-triggered surface stimulation, which may find instances in many...
To meet the emerging demand of high-throughput intimate interfaces in neuroscience research and neural prosthetics, a multilayer wiring interconnect technology for implementing high-density, integratable polydimethylsiloxane (PDMS) based conformable microelectrode arrays (MEAs) is developed. This technology has two parts: first, multilayer interconnects are fabricated within PDMS, which provides the...
A method for fabricating polydimethylsiloxane (PDMS) based conformable microelectrode arrays (MEAs) with selectable novel 3-D microelectrode geometries is presented. Simply recessed, conically recessed, exponentially recessed, and protruded-well microelectrodes have been fabricated on the MEA with a diameter as small as 10 mum. 3-D microelectrode geometry parameters (recess depth, recess slope &...
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