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Evidence has emerged indicating that the ε4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD.The aim of this study was to investigate interaction effects of the APOE ε4 allele and the alleles at the single-nucleotide...
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