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Previous acute canine experiments indicated that asynchronous electrical activation reduces mechanical load and blood flow in early activated regions and increases them in late activated regions. We investigated the structural adaptation and the distribution of blood flow in the left ventricular (LV) wall during chronic asynchronous activation, as induced by ventricular pacing. Under general anaesthesia...
Various kinds of abnormal, asynchronous electric activation of the left ventricle (LV) decrease mechanical load in early versus late activated regions of the ventricular wall. Because myocardium usually adapts its mass to changes in workload, we investigated by echocardiography whether regional differences in wall thickness are present in two kinds of asynchronous electric activation of different...
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