The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
A new series of polyamine–toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons. The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines (e.g., L1210, HeLa and B16) and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B16 cell line. Of these...
Four novel dicyclic arene–homospermidine conjugates (6a–d) were synthesized and evaluated for cytotoxicity in L1210, α-difluoromethylornithine (DFMO) treated L1210, melanoma B16, spermidine (SPD) treated B16, and Hela cells. In the DFMO-treated L1210 experiments, 6a–d were more sensitive to DFMO than naphthalene-homospermidine (6e), suggesting that 6a–d can utilize the polyamine transporter (PAT)...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.