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Patients with nephrolithiasis can develop ureteral stricture or sustain ureteral injury during attempts at stone removal. While some of these can be addressed with an endourologic approach, certain patients will need to undergo a major ureteral reconstructive procedure such as ileal ureter and other bowel substitution of the ureter, Boari flap, or autotransplantation. An extremely small number of...
To determine whether glyoxal can be converted to oxalate in human erythrocytes. Glyoxal synthesis is elevated in diabetes, cardiovascular disease, and other diseases with significant oxidative stress. Erythrocytes are a good model system for such studies as they lack intracellular organelles and have a simplified metabolism.Erythrocytes were isolated from healthy volunteers and incubated with varying...
Dietary modifications should be considered as a first line approach in the treatment of idiopathic calcium oxalate nephrolithiasis. The amounts of oxalate and calcium consumed in the diet are significant factors in the development of the disease due to their impact on urinary oxalate excretion. There are a number of strategies that can be employed to reduce oxalate excretion. The consumption of oxalate-rich...
In humans, approximately 60 mg of ascorbic acid (AA) breaks down in the body each day and has to be replaced by a dietary intake of 70 mg in women and 90 mg in men to maintain optimal health and AA homeostasis. The breakdown of AA is non-enzymatic and results in oxalate formation. The exact amount of oxalate formed has been difficult to ascertain primarily due to the limited availability of healthy...
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