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p15 INK4b functions as a tumor suppressor and implicated in cellular senescence. Here, we show that the Oct-1 binding site in the human p15 INK4b gene promoter functions as a silencer. Oct-1 specifically interacts with this binding site in vitro and in vivo and SMRT and HDAC1 are present in the p15 INK4b proximal promoter region. Moreover, mouse embryo fibroblasts (MEFs) lacking...
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