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Steroidogenic factor 1 (SF-1) is a nuclear receptor that plays important roles in the hypothalamus–pituitary–steroidogenic organ axis. Global knockout studies in mice revealed the essential in vivo roles of SF-1 in the ventromedial hypothalamic (VMH) nucleus, adrenal glands, and gonads. One limitation of global SF-1 knockout mice is their early postnatal death from adrenocortical insufficiency. To...
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