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Active immunization with myelin basic protein (MBP) induces experimental allergic encephalomyelitis (EAE) in a variety of animal species, including rats and mice. We have previously described the ability of the newly described mouse lambda (λ) variable (V) region, Vλx, to confer MBP reactivity to an Ab. In this report, we have evaluated the heavy (H) chain isotype distribution of Vλx-bearing Abs in...
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