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Tumor necrosis factor α plays primary role in the pathogenesis of inflammatory diseases. TNFα is essential for antigen-specific IgE production and for the induction of Th2-type cytokines. The lack of TNFα inhibited the development of allergic rhinitis. In this study, the chimeric gene of soluble TNF receptor and IgGFc fragment (sTNFR-IgGFc) was cloned into the EBV-based plasmid pGEG. When the plasmid...
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