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Agonists of the peroxisome proliferator-activated receptor gamma (PPARγ) exert anti-inflammatory and anti-proliferative effects which led to testing of these drugs in experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. In contrast, the effect of PPARdelta (PPARδ) agonists in EAE is not yet known. We show that oral administration of the selective PPARδ agonist GW0742 reduced...
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