Search results for: Friedrich Altmann

Items from 1 to 20 out of 96 results

article

EAACI Molecular Allergology User's Guide 2.0

Stephanie Dramburg, Christiane Hilger, Alexandra F. Santos, Leticia Vecillas, more

Pediatric Allergy and Immunology > 34 > S28 > n/a - n/a

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In...

article

N‐Glycan profiling of chondrocytes and fibroblast‐like synoviocytes: Towards functional glycomics in osteoarthritis

Johannes Fuehrer, Katharina M. Pichler, Anita Fischer, Alexander Giurea, more

PROTEOMICS – Clinical Applications > 15 > 2-3 > n/a - n/a

Purpose N‐Glycan profiling provides an indicator of the cellular potential for functional pairing with tissue lectins. Following the discovery of galectin expression by chondrocytes as a factor in osteoarthritis pathobiology, mapping of N‐glycans upon their phenotypic dedifferentiation in culture and in fibroblast‐like synoviocytes is a step to better understand glycobiological contributions to disease...

article

The Degree and Length of O‐Glycosylation of Recombinant Proteins Produced in Pichia pastoris Depends on the Nature of the Protein and the Process Type

Bojana Radoman, Clemens Grünwald‐Gruber, Bernhard Schmelzer, Domen Zavec, more

Biotechnology Journal > 16 > 3 > n/a - n/a

The methylotrophic yeast Pichia pastoris is known as an efficient host for the production of heterologous proteins. While N‐linked protein glycosylation is well characterized in P. pastoris there is less knowledge of the patterns of O‐glycosylation. O‐glycans produced by P. pastoris consist of short linear mannose chains, which in the case of recombinant biopharmaceuticals can trigger an immune response...

article

Individuals with IgE antibodies to α‐Gal and CCD show specific IgG subclass responses different from subjects non‐sensitized to oligosaccharides

Patricia Román‐Carrasco, Wolfgang Hemmer, Christoph Klug, Anja Friedrich, more

Clinical & Experimental Allergy > 50 > 9 > 1107 - 1110

article

A first view on the unsuspected intragenus diversity of N‐glycans in Chlorella microalgae

Réka Mócsai, Rudolf Figl, Leander Sützl, Silvia Fluch, more

The Plant Journal > 103 > 1 > 184 - 196

Chlorella microalgae are increasingly used for various purposes such as fatty acid production, wastewater processing, or as health‐promoting food supplements. A mass spectrometry‐based survey of N‐glycan structures of strain collection specimens and 80 commercial Chlorella products revealed a hitherto unseen intragenus diversity of N‐glycan structures. Differing numbers of methyl groups, pentoses,...

article

Peptidoglycan-type analysis of the N-acetylmuramic acid auxotrophic oral pathogen Tannerella forsythia and reclassification of the peptidoglycan-type of Porphyromonas gingivalis

Valentina M. T. Mayer, Isabel Hottmann, Rudolf Figl, Friedrich Altmann, more

BMC Microbiology > 2019 > 19 > 1 > 1-9

Background Tannerella forsythia is a Gram-negative oral pathogen. Together with Porphyromonas gingivalis and Treponema denticola it constitutes the “red complex” of bacteria, which is crucially associated with periodontitis, an inflammatory disease of the tooth supporting tissues that poses a health burden worldwide. Due to the absence of common peptidoglycan biosynthesis genes, the unique bacterial...

article

Production of a recombinant peroxidase in different glyco-engineered Pichia pastoris strains: a morphological and physiological comparison

Alexander Pekarsky, Lukas Veiter, Vignesh Rajamanickam, Christoph Herwig, more

Microbial Cell Factories > 2018 > 17 > 1 > 1-15

Background The methylotrophic yeast Pichia pastoris is a common host for the production of recombinant proteins. However, hypermannosylation hinders the use of recombinant proteins from yeast in most biopharmaceutical applications. Glyco-engineered yeast strains produce more homogeneously glycosylated proteins, but can be physiologically impaired and show tendencies for cellular agglomeration, hence...

article

Reductive Alkaline Release of N‐Glycans Generates a Variety of Unexpected, Useful Products

Rudolf Figl, Friedrich Altmann

PROTEOMICS > 18 > 3-4 > n/a - n/a

Release of O‐glycans by reductive β‐elimination has become routine in many glyco‐analytical laboratories and concomitant release of N‐glycans has repeatedly been observed. Revisiting this somewhat forgotten mode of N‐glycan release revealed that all kinds of N‐glycans including oligomannosidic and complex‐type N‐glycans from plants with 3‐linked fucose and from mammals with or without 6‐linked fucose...

article

ImmunoCAP cellulose displays cross-reactive carbohydrate determinant (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD IgE antibody levels

Wolfgang Hemmer, Friedrich Altmann, Friedrich Holzweber, Clemens Gruber, more

Journal of Allergy and Clinical Immunology > 2018 > 141 > 1 > 372-381.e3

Cross-reactive carbohydrate determinants (CCDs) in plants and insect venoms are a common cause of irrelevant positive test results during in vitro allergy diagnosis. We observed that some CCD-positive sera show nonspecific IgE binding even with CCD-free recombinant allergens when using the Phadia ImmunoCAP platform.We investigated whether cellulose used as an allergen carrier in ImmunoCAP harbors...

article

Glycan profile of CHO derived IgM purified by highly efficient single step affinity chromatography

Julia Hennicke, Anna Maria Lastin, David Reinhart, Clemens Grünwald-Gruber, more

Analytical Biochemistry > 2017 > 539 > C > 162-166

Immunoglobulin M (IgM) antibodies are reckoned as promising tools for therapy and diagnostic approaches. Nevertheless, the commercial success of IgMs is hampered due to bottlenecks in recombinant production and downstream processing. IgMs are large, complex and highly glycosylated proteins that are only stable in a limited range of conditions. To investigate these sensitive IgM antibodies we optimized...

article

IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice

Daniela Kao, Anja Lux, Anja Schaffert, Roland Lang, more

European Journal of Immunology > 47 > 12 > 2070 - 2079

Immunoglobulin G (IgG) glycosylation can modulate antibody effector functions. Depending on the precise composition of the sugar moiety attached to individual IgG glycovariants either pro‐ or anti‐inflammatory effector pathways can be initiated via differential binding to type I or type II Fc‐receptors. However, an in depth understanding of how individual IgG subclasses are glycosylated during the...

article

Recombinant plant-derived human IgE glycoproteomics

Laura Montero-Morales, Daniel Maresch, Alexandra Castilho, Aysegül Turupcu, more

Journal of Proteomics > 2017 > 161 > C > 81-87

The increasing biotechnological interest in human IgE antibodies demands advanced systems which allow their proper expression. However, this is still a challenge due to the complexity of the molecule, particularly regarding the diverse N-glycosylation pattern. Here, we present the expression of recombinant IgE in wild type and glycan-engineered Nicotiana benthamiana plants and in-depth N-glycosylation...

article

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination

Yasir A. Syed, Chao Zhao, Don Mahad, Wiebke Möbius, more

Acta Neuropathologica > 2017 > 134 > 1 > 167-168

The online version of the original article can be found under doi: 10.1007/s00401-015-1521-1 .

article

Disruption of genes involved in CORVET complex leads to enhanced secretion of heterologous carboxylesterase only in protease deficient Pichia pastoris

Lukas Marsalek, Clemens Gruber, Friedrich Altmann, Markus Aleschko, more

Biotechnology Journal > 12 > 5 > n/a - n/a

The methylotrophic yeast Pichia pastoris (Komagataella spp.) is a popular microbial host for the production of recombinant proteins. Previous studies have shown that mis‐sorting to the vacuole can be a bottleneck during production of recombinant secretory proteins in yeast, however, no information was available for P. pastoris. In this work the authors have therefore generated vps (vacuolar protein...

article

Letter to the Editor regarding “Analysis of recombinant human follicle-stimulating hormone by mass spectrometric approaches”

Clemens Grünwald-Gruber, Friedrich Altmann

Analytical and Bioanalytical Chemistry > 2017 > 409 > 15 > 3899-3900

article

Determination of true ratios of different N-glycan structures in electrospray ionization mass spectrometry

Clemens Grünwald-Gruber, Andreas Thader, Daniel Maresch, Thomas Dalik, more

Analytical and Bioanalytical Chemistry > 2017 > 409 > 10 > 2519-2530

An ideal method for the analysis of N-glycans would both identify the isomeric structure and deliver a true picture of the relative, if not absolute, amounts of the various structures in one sample. Porous graphitic carbon chromatography coupled with electrospray ionization mass spectrometry (ESI-MS) detection has emerged as a method with a particularly high potential of resolving isomeric oligosaccharides,...

article

“Hypermethylation” of anthranilic acid-labeled sugars confers the selectivity required for liquid chromatography-mass spectrometry

Markus Windwarder, Rudolf Figl, Elisabeth Svehla, Réka Tünde Mócsai, more

Analytical Biochemistry > 2016 > 514 > C > 24-31

Analysis of the monosaccharides of complex carbohydrates is often performed by liquid chromatography with fluorescence detection. Unfortunately, methylated sugars, unusual amino- or deoxysugars and incomplete hydrolysis can lead to erroneous assignments of peaks. Here, we demonstrate that a volatile buffer system is suitable for the separation of anthranilic acid labeled sugars. It allows off-line...

article

Corrigendum to “Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells” [J. Biotechnol. 227 (2016) 120–130]

Elisabeth Gludovacz, Daniel Maresch, Maximilian Bonta, Helen Szöllösi, more

Journal of Biotechnology > 2016 > 231 > C > 295

article

Characterization of recombinant human diamine oxidase produced in Chinese Hamster Ovary cells

Elisabeth Gludovacz, Daniel Maresch, Maximilian Bonta, Helen Szöllösi, more

New Biotechnology > 2016 > 33 > S > S33

article

Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells

Elisabeth Gludovacz, Daniel Maresch, Maximilian Bonta, Helen Szöllösi, more

Journal of Biotechnology > 2016 > 227 > C > 120-130

Human diamine oxidase (hDAO) efficiently degrades polyamines and histamine. Reduced enzyme activities might cause complications during pregnancy and be involved in histamine intolerance. So far hDAO has been characterized after isolation from either native sources or the heterologous production in insect cells. Accessibility to human enzyme is limited and insect cells produce non-human glycosylation...

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Content availability

Available (95)
None (1)

Keywords

GLYCOPROTEIN (9)
GLYCOSYLATION (7)
CROSS-REACTIVE CARBOHYDRATE DETERMINANTS (5)
GLYCOSYLTRANSFERASE (5)
MASS SPECTROMETRY (5)
N-GLYCAN (5)
N-GLYCANS (5)
ARABIDOPSIS (4)
ARABIDOPSIS THALIANA (4)
CHO (4)
CARBOHYDRATE EPITOPES (3)
FOOD ALLERGY (3)
FUCOSYLTRANSFERASE (3)
GLYCOPROTEINS (3)
GLYCOPROTEOMICS (3)
GLYCOSYLTRANSFERASES (3)
N-GLYCOSYLATION (3)
NICOTIANA BENTHAMIANA (3)
O-GLYCOSYLATION (3)
SIALYLATION (3)
PICHIA PASTORIS (2)
ASPARAGINE-LINKED OLIGOSACCHARIDES (2)
CAENORHABDITIS (2)
CCDS (2)
CHONDROCYTES (2)
CROSS-REACTIVE CARBOHYDRATE DETERMINANT (2)
DROSOPHILA (2)
ELECTRON-TRANSFER DISSOCIATION (2)
ENDOPLASMIC RETICULUM (2)
FUCOSE (2)
GLYCAN (2)
GLYCOBIOLOGY (2)
GLYCOMICS (2)
HORSERADISH PEROXIDASE (2)
HUMAN GROWTH HORMONE (2)
IGE (2)
INSECT CELLS (2)
MOLECULAR FARMING (2)
N-LINKED GLYCANS (2)
OCH1 (2)
OLIGOSACCHARIDE (2)
PICHIA PASTORIS (2)
PLANT CELL WALL (2)
POROUS GRAPHITIC CARBON (2)
PROTEASE (2)
PROTEOME (2)
RECOMBINANT EXPRESSION (2)
SECRETION (2)
SIALIC ACID (2)
SOMATOTROPIN (2)
TRANSGENIC PLANTS (2)
TWO-CHAIN FORM (2)
O-GALNAC GLYCAN (1)
O-GLYCOSYLATION (1)
PICHIA PASTORIS (1)
ARABIDOPSIS (1)
ARABIDOPSIS THALIANA (1)
BIOMPHALARIA GLABRATA (1)
MEDICAGO TRUNCATULA (1)
N-ACETYLGLUCOSAMINYLTRANSFERASE (1)
N-ACETYLGLUCOSAMINYLTRANSFERASE I (1)
N-GLYCAN MODIFICATION (1)
O-GLYCOSYLATION MOTIF (1)
3-DEOXY-D-MANNO-2-OCTULOSONIC ACID (1)
6-DEOXY TALOSE (1)
ABIOTIC STRESS (1)
AFFINITY PURIFICATION (1)
ALLERGY (1)
ALLERGY DIAGNOSIS (1)
ALMOND (1)
ALPHA-GAL (1)
AMILORIDE-SENSITIVE AMINE OXIDASE (1)
ANAPHYLAXIS (1)
ANTHRANILIC ACID (1)
ANTI-INFLAMMATORY (1)
ANTIBODY FRAGMENT (1)
ANTIBODY GLYCOSYLATION (1)
ANTI‐CARBOHYDRATE IGES (1)
AOC1 (1)
ARABINOGALACTAN PROTEIN (1)
ARABINOSE (1)
ASTHMA (1)
ATFUC95A (1)
ATOPIC DERMATITIS (1)
BACTERIOPHAGE (1)
BACULOVIRUS (1)
BASOPHIL ACTIVATION TEST (1)
BEE VENOM OLIGOSACCHARIDES (1)
BINDING AFFINITY (1)
BIOREACTOR (1)
BIOREACTOR CULTIVATION (1)
BIOSIMILAR (1)
C TYPE LECTIN RECEPTORS (1)
CAPSULAR POLYSACCHARIDE (1)
CARBOHYDRATE DETERMINANT (1)
CARBOHYDRATES (1)
CARROT ALLERGY (1)
CARROT PROFILIN (1)
CATALASE-PEROXIDASE (1)
CCD (1)
more

Data set

Elsevier (42)
Springer (34)
Wiley (16)
ACS (4)

Journal

Glycoconjugate Journal (11)
Phytochemistry (6)
The Journal of Allergy and Clinical Immunology (6)
Analytical Biochemistry (5)
Journal of Biotechnology (5)
The Plant Journal (4)
Acta Neuropathologica (3)
Analytical Chemistry (3)
Analytical and Bioanalytical Chemistry (3)
Applied Microbiology and Biotechnology (3)
BBA - General Subjects (3)
PROTEOMICS (3)
Plant Biotechnology Journal (3)
Plant Molecular Biology (3)
Biochimie (2)
Biotechnology Journal (2)
Current Opinion in Biotechnology (2)
European Food Research and Technology (2)
Journal of Proteomics (2)
Microbial Cell Factories (2)
Planta (2)
Allergo Journal International (1)
Archives of Microbiology (1)
BBA - Molecular and Cell Biology of Lipids (1)
BMC Biology (1)
BMC Microbiology (1)
Carbohydrate Research (1)
Clinical & Experimental Allergy (1)
European Journal of Immunology (1)
FEBS Letters (1)
FEMS Microbiology Letters (1)
Journal of Allergy and Clinical Immunology (1)
Journal of Clinical Immunology (1)
Journal of Controlled Release (1)
Journal of Proteome Research (1)
New BIOTECHNOLOGY (1)
New Biotechnology (1)
PROTEOMICS – Clinical Applications (1)
Pediatric Allergy and Immunology (1)
Plant Physiology and Biochemistry (1)
Plant Science (1)
Protein Expression and Purification (1)
more

INFONA - science communication portal

Search results for: Friedrich Altmann

EAACI Molecular Allergology User's Guide 2.0

N‐Glycan profiling of chondrocytes and fibroblast‐like synoviocytes: Towards functional glycomics in osteoarthritis

The Degree and Length of O‐Glycosylation of Recombinant Proteins Produced in Pichia pastoris Depends on the Nature of the Protein and the Process Type

Individuals with IgE antibodies to α‐Gal and CCD show specific IgG subclass responses different from subjects non‐sensitized to oligosaccharides

A first view on the unsuspected intragenus diversity of N‐glycans in Chlorella microalgae

Peptidoglycan-type analysis of the N-acetylmuramic acid auxotrophic oral pathogen Tannerella forsythia and reclassification of the peptidoglycan-type of Porphyromonas gingivalis

Production of a recombinant peroxidase in different glyco-engineered Pichia pastoris strains: a morphological and physiological comparison

Reductive Alkaline Release of N‐Glycans Generates a Variety of Unexpected, Useful Products

ImmunoCAP cellulose displays cross-reactive carbohydrate determinant (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD IgE antibody levels

Glycan profile of CHO derived IgM purified by highly efficient single step affinity chromatography

IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice

Recombinant plant-derived human IgE glycoproteomics

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination

Disruption of genes involved in CORVET complex leads to enhanced secretion of heterologous carboxylesterase only in protease deficient Pichia pastoris

Letter to the Editor regarding “Analysis of recombinant human follicle-stimulating hormone by mass spectrometric approaches”

Determination of true ratios of different N-glycan structures in electrospray ionization mass spectrometry

“Hypermethylation” of anthranilic acid-labeled sugars confers the selectivity required for liquid chromatography-mass spectrometry

Corrigendum to “Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells” [J. Biotechnol. 227 (2016) 120–130]

Characterization of recombinant human diamine oxidase produced in Chinese Hamster Ovary cells

Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Friedrich Altmann

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options