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Nerve ligation injury in rats may represent a useful model of some clinical neuropathic pains. Activation ofN -methyl-d-aspartate (NMDA) receptors may maintain central sensitivity and contribute to neuropathic pain. Here, nerve injury was produced by unilateral ligation of the L5 and L6 spinal roots of the sciatic nerve of rats. Catheters were inserted for intrathecal (i.th.) or local delivery...
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