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First-generation Ca2+channel antagonists depress myocardial contractility, but many of the newer Ca2+channel blockers have a high degree of “vascular selectivity”. This study compares the effects of the Ca2+antagonists felodipine, amlodipine, mibefradil, verapamil and nifedipine, and the Ca2+channel agonist, (S)(−)-Bay K-8644 on Ca2+transient amplitudes in fura-2/AM-loaded rat and canine ventricular...
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