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The cerebral hemispheres are differentially involved in regulating immunological functioning and the neuropathology associated with Alzheimer's disease (AD) is asymmetrical. Thus, subgroups of AD patients may exhibit different patterns of immunological dysfunction. We explored this possibility in a group of AD patients and found that patients with low white blood cell counts and low lymphocyte numbers...
J. Neurochem. (2011) 119, 189–201.
AbstractDiverse lines of evidence indicate that pre‐fibrillar, diffusible assemblies of the amyloid β‐protein (Aβ) play an important role in Alzheimer’s disease pathogenesis. Although the precise molecular identity of these soluble toxins remains unsettled, recent experiments suggest that sodium dodecyl sulfate (SDS)‐stable Aβ dimers may be the basic building blocks...
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