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The inhibitory effect of a series of novel structurally related compounds on the human UDP-glucuronosyltransferase UGT1 * 6 stably expressed in a V79 cell line was investigated. The inhibitors contain a lipophilic N-acyl phenylaminoalcohol residue and a uridine moiety connected by a spacer varying for each compound. The effects of these compounds on the glucuronidation reaction measured with...
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