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Methods for individual participant data meta‐analysis of survival outcomes commonly focus on the hazard ratio as a measure of treatment effect. Recently, Siannis et al. (2010, Statistics in Medicine 29:3030–3045) proposed the use of percentile ratios as an alternative to hazard ratios. We describe a novel two‐stage method for the meta‐analysis of percentile ratios that avoids distributional assumptions...
Methodology for the meta‐analysis of individual patient data with survival end‐points is proposed. Motivated by questions about the reliance on hazard ratios as summary measures of treatment effects, a parametric approach is considered and percentile ratios are introduced as an alternative to hazard ratios. The generalized log‐gamma model, which includes many common time‐to‐event distributions as...
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