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Iron is necessary for life but also a potent pro-oxidant implicated in the pathogenesis of age-related diseases. We sought to determine if iron levels change with age and by sex in various tissues from several commonly studied mouse strains. Brain, liver, heart, retina, and retinal pigment epithelium (RPE)/choroid were dissected from male and female mice of young adult (2–6month old) and aged (16–19month...
Physiological consequences of early stages of photoreceptor degeneration were examined in heterozygous P23H rhodopsin transgenic (Tg) and in aging normal Sprague-Dawley rats. Rod photoreceptor and rod bipolar (RB) cell function were estimated with maximum value and sensitivity parameters of P3 and P2 components of the electroretinogram. In both Tg and aging normal rats, the age-related rate of decline...
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