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Objective: To determine whether the opioidergic system is involved in the modulation of leptin secretion in healthy and amenorrheic subjects.Design: Prospective study.Setting: Department of Obstetrics and Gynecology, University of Modena, Modena, Italy.Patient(s): Healthy subjects (n = 8) and patients with hypothalamic amenorrhea (n = 17) or hyperandrogenism (n = 7) and low body mass index (BMI).Intervention(s):...
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