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Squamous cell carcinoma is the most common malignant tumor of the oral cavity and its adjacent sites, which endangers the physical and mental health of patients and has a complex etiology. Chronic infection is considered to be a risk factor in cancer development. Evidence suggests that periodontal pathogens, such as Porphyromonas gingivalis, Fusobacterium nucleatum, and Treponema denticola, are associated...
Purpose
The aim of this study was to systematically review and assess the diagnostic accuracy of Raman spectroscopy (RS) for oral cancer tissue, oral precancerous lesions, and normal oral tissue.
Methods
PubMed, Embase, Web of Science, the China National Knowledge Infrastructure, and gray literature were searched for all relevant articles published before July 2019. We used the Quality Assessment...
BACKGROUND
13‐Cis retinoic acid (13‐CRA) is a synthetic vitamin A derivative. High‐dose 13‐CRA in patients with squamous cell cancers of the head and neck (SCCHNs) reduces the incidence of second primary tumors (SPTs). The authors report long‐term results from a phase 3 randomized trial that compared treatment with low‐dose 13‐CRA versus placebo for patients who had early stage SCCHN, with a focus...
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