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Background & Aims
Hepatitis B virus (HBV) infection is the most critical factor underlying liver cirrhosis and hepatocellular carcinoma worldwide. IL‐1β and IL‐18, generated by activation of the inflammasome/caspase‐1 signaling pathway, play important roles in the control and clearance of HBV. However, the specific relationship between the inflammasome response and IFN‐α resistance or viral persistence...
Background & Aims
Serum Golgi protein 73 (GP73) is a potential biomarker for fibrosis assessment. We aimed to develop an algorithm based on GP73 and liver stiffness (LS) for further improvement of accuracy for significant fibrosis in patients with antiviral‐naïve chronic hepatitis B virus (HBV) infection.
Methods
Diagnostic accuracy evaluation of GP73 and development of GP73‐LS algorithm was...
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