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Front Cover: The cover image is based on the Research Article FANCL gene mutations in premature ovarian insufficiency by Yajuan Yang et al., https://doi.org/10.1002/humu.23997.
The Fanconi anemia (FA) pathway is mainly involved in DNA interstrand crosslinks (ICLs) repair in the genome. Several FA genes, including FANCD1/BRCA2, FANCM, and FANCU/XRCC2, have been identified as causative genes for premature ovary insufficiency (POI). Fanconi anemia group L protein (FANCL) cooperates with FANCT/UBE2T to ubiquitinate the FANCI‐D2 dimer, which is a crucial event in the process...
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