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Epithelial-mesenchymal interactions areresponsible for the unique pattern of ductal branchingmorphogenesis characteristic of the mammary gland. Toinvestigate the factors which control the elongation and branching of lactiferous ducts, wedeveloped an in vitro model of ductal morphogenesis inwhich clonal mouse mammary epithelial cells (TAC-2cells) are grown in collagen gels. In this experimentalsystem,...
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