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Although glucocorticoids accelerate fetal lung maturation, it has been repeatedly observed that this therapy is only 50% effective in prevention of respiratory distress syndrome (RDS). Previous studies (Torday, Endocrinology 126:3240, 1990) had shown that fetal adrenal androgens (FAA) block steroid-stimulated fetal lung maturation. Based on the hypothesis that steroids must suppress FAA to accelerate...
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