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Arginine kinase plays an important role in the cellular energy metabolism of invertebrates. We investigated the effects of Zn 2+ on the enzymatic activity and unfolding and aggregation of Euphausia superba arginine kinase (ESAK). Zn 2+ inhibited the activity of ESAK (IC 50 =0.027±0.002mM) following first-order kinetics consistent with the transition from a mono-phasic to a...
α-Glucosidase (EC 3.2.1.20) is a critical enzyme with clinical relevance to type 2 diabetes mellitus. Therefore, research on this enzyme's inhibition is important. In the present study, we investigated Zn 2+ -induced inhibition and the structural changes of α-glucosidase. α-Glucosidase activity was significantly inhibited by Zn 2+ in a dose-dependent manner. The inhibition followed...
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