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The aim of this work was to optimize the glycoside composition of Stevia rebaudiana leaves using supercritical fluid extraction (SFE). A Box-Behnken statistical design was used to evaluate the effect of various values of pressure (150–350bar), temperature (40–80°C) and concentration of ethanol-water mixture (70:30) as co-solvent (0–20%) by CO 2 flow rate of 15gmin −1 for 60min. The...
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