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Precisely delivering light to multiple locations in biological tissue is crucial for advancing multiregional optogenetics in neuroscience research. However, conventional implantable devices typically have rigid geometries and limited light sources, allowing only single or dual probe placement with fixed spacing. Here, a fully flexible optogenetic device with multiple thin‐film microscale light‐emitting...
Layered Clay Minerals
In article number 2300842, Weimin Xie, Ying Chen, and Huaming Yang review the current applications of layered clay minerals (LCM) in cancer therapy. Except for being used as drug delivery carriers, it can also produce reactive oxygen species, hydroxyl radicals, as an embolic agent, promote immune effects, adhesive cancer cells to prevent metastasis and their own antitumor effects...
3D printing technology has demonstrated great potential in fabricating flexible and customizable high‐performance batteries, which are highly desired in the forthcoming intelligent and ubiquitous energy era. However, a significant performance gap, especially in cycling stability, still exists between the 3D‐printed and conventional electrodes, seriously limiting the practical applications of 3D‐printed...
Cancer is one of the deadliest diseases, and current treatment regimens suffer from limited efficacy, nonspecific toxicity, and chemoresistance. With the advantages of good biocompatibility, large specific surface area, excellent cation exchange capacity, and easy availability, clay minerals have been receiving ever‐increasing interests in cancer treatment. They can act as carriers to reduce the toxic...
In the context of thin‐film nanocomposite membranes with interlayer (TFNi), nanoparticles are deposited uniformly onto the support prior to the formation of the polyamide (PA) layer. The successful implementation of this approach relies on the ability of nanoparticles to meet strict requirements regarding their sizes, dispersibility, and compatibility. Nevertheless, the synthesis of covalent organic...
As an emerging two‐dimensional semiconductor, rhenium disulfide (ReS2) is renowned for its strong in‐plane anisotropy in electrical, optical, and thermal properties. In contrast to the electrical, optical, optoelectrical, and thermal anisotropies that are extensively studied in ReS2, experimental characterization of mechanical properties has largely remained elusive. Here, it is demonstrated that...
Nanobody‐Natural Killer Cell Conjugates
In article number 2103463, Zhimeng Wu, Zhaohui Huang, and co‐workers construct a nanobody‐NK92MI cell conjugate through natural killer (NK) cell surface metabolic glycoengineering and biocompatible copper free click chemistry for solid tumor adoptive immunotherapy. The nanobody‐engineered NK cell conjugates gain excellent cancer tissue penetration capability...
Cancer immunotherapy based on natural killer (NK) cells is demonstrated to be a promising strategy. However, NK cells are deficient in ligands that target specific tumors, resulting in limited antitumor efficacy. Here, a glycoengineering approach to imitate the chimeric antigen receptor strategy and decorate NK cells with nanobodies to promote NK‐based immunotherapy in solid tumors is proposed. Nanobody...
In article number 2000546, Jiankang He, Xin Zhao, and co‐workers report a human‐on‐leaf#x02010;chip system with biomimetic multiscale vasculature systems connecting vascularized organs, mimicking the complex in vivo architectures of the human cardiovascular system. The native organ‐to‐organ crosstalk is well recapitulated, implicating a strong potential for harnessing the leaf chip for circulatory‐related...
The vascular network is a central component of the organ‐on‐a‐chip system to build a 3D physiological microenvironment with controlled physical and biochemical variables. Inspired by ubiquitous biological systems such as leaf venation and circulatory systems, a fabrication strategy is devised to develop a biomimetic vascular system integrated with freely designed chambers, which function as niches...
Photodynamic therapy (PDT) is a promising technique for cancer therapy, providing good therapeutic efficacy with minimized side effect. However, the lack of oxygen supply in the hypoxic tumor site obviously restricts the generation of singlet oxygen (1O2), thus limiting the efficacy of PDT. So far, the strategies to improve PDT efficacy usually rely on complicated nanosystems, which require sophisticated...
To address demands for increased data transmission rates, electrically small antennas (ESAs) that simultaneously offer large frequency bandwidths and small physical sizes are of growing interest. 3D layouts are particularly important in this context and among various 3D ESAs, systems that adopt hemispherical shapes are very promising, because they can occupy the entire Chu‐sphere and offer outstanding...
A feasible approach is reported to reduce the switching current and increase the nonlinearity in a complementary metal–oxide–semiconductor (CMOS)‐compatible Ti/SiNx/p+‐Si memristor by simply reducing the cell size down to sub‐100 nm. Even though the switching voltages gradually increase with decreasing device size, the reset current is reduced because of the reduced current overshoot effect. The scaled...
A well‐defined morphology of anatase TiO2 with a high percentage of {001} facets is of particular importance for optimizing photocatalytic performance. In article number 1604115, by Zhaohui Ren, Gaorong Han, and co‐workers, ultrathin anatase TiO2 nanosheets ≈2.5 nm in thickness and ≈200 nm in side‐length are prepared by an ethanol solvothermal route, giving rise to ≈97% of the {001} facets being exposed...
An ethanol solvothermal route has been developed to prepare ultrathin anatase TiO2 nanosheets with dominant {001} facets (≈97%), a thickness of ≈2.5 nm, and a side length of ≈200 nm. The introduction of ethanol solvent significantly enhances the content of surface chemisorbed F− on the TiO2 nanosheet, which has a higher stability and further lowers the surface energy of {001} facets, giving rise to...
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