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The serine protease subtilisin‐A (SubA) induces a form of long‐term depression (LTD) of synaptic transmission in the rat hippocampus, and molecular changes associated with SubA‐induced LTD (SubA‐LTD) were explored by using recordings of evoked postsynaptic potentials and immunoblotting. SubA‐LTD was prevented by a selective inhibitor of SubA proteolysis, but the same inhibitor did not affect LTD induced...
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