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Purpose Our previous studies showed that combined treatment of oxaliplatin and N1, N11diethyl-norspermine (DENSPM) results in massive induction of spermidine/spermine N1-acetyltransferase (SSAT) mRNA and activity. Since oxaliplatin and 5-fluorouracil (5FU) are used clinically in treatment of colorectal cancers, this study examines the effect of adding DENSPM to oxaliplatin/5FU combination...
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