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Targeted ultrasound contrast agents, comprising shell stabilized gas filled microbubbles (MBs), can be used to detect molecular markers of disease present on the vascular endothelium. Current MB imaging techniques exploit the nonlinear echo response of microbubbles to provide signal contrast with respect to adjacent tissue signal. However, these methods are hampered by false positive artifacts arising...
Targeted microbubbles are currently used as ultrasound contrast agents in pre-clinical studies to visualize disease markers present on the blood vessel endothelium. Rapid clinical translation of targeted microbubble imaging requires a minimization of the diagnostically effective microbubble dose. In this study, we demonstrate an imaging method that improves signal-to-noise ratio (SNR) for microbubble...
Nonlinear echo signals from microbubbles are commonly isolated and visualized using techniques such as pulse inversion (PI) or contrast pulse sequences (CPS). Although these methods function by suppressing the linear signal component, they are still susceptible to detection of a false-positive nonlinear signal arising from strong tissue interfaces. In this study, acoustic radiation force (ARF) was...
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