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Previously, we have shown that subcutaneous administration of insulin stimulates ornithine decarboxylase (ODC) mRNA expression and enzymatic activity in the liver of infant control rats, but not in those pretreated intracerebroventricularly (i.c.v.) with β-endorphin. This finding is consistent with the hypothesis that β-endorphin synthesized in the brain plays a prime role in the control of postnatal...
We have previously shown that intracerebroventricular administration of relatively low doses of β-endorphin suppresses basal levels of hepatic ODC activity as well as tissue ODC responsiveness to administered insulin in developing rats. Using Northern blotting analysis, the current studies examine whether these effects of CNS β-endorphin may be mediated by changes in ODC gene expression. Subcutaneous...
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