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The effect of etomidate, an imidazole general anesthetic, on GABA A receptor function was studied in cultured hippocampal neurons. At a clinically relevant concentration of 4.1 μM, etomidate shifts the GABA dose response to the left (ED 50 shift from 10.2 to 5.2 μ M), with no change in the maximum current evoked by saturating concentrations of GABA. At a higher concentration of 82...
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