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The aim of this study is to evaluate the potency of piboserod (SB 207266), a selective 5-HT4 receptor antagonist, at inhibiting the 5-HT4-mediated potentiating effect of serotonin (5-HT) on the neurally-mediated contractile responses of human detrusor strips to electrical field stimulations (EFS). Strips of human detrusor muscle were mounted in Krebs-HEPES buffer under a resting tension of 500 mg...
Abstract The spinal cord contains a network that controls erection. This network can be activated by information from the periphery and by supraspinal nuclei. Besides anatomical studies that have detailed central pathways putatively involved in the central process of proerectile information, functional approaches have focused on pharmacological manipulations of specific systems, e.g. central dopaminergic...
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