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A role for the Fc receptor β chain (FcRβ) in the pathogenesis of allergy has been suggested by genetic studies. FcRβ is a subunit common to the high-affinity IgE (FcεRI) and low-affinity IgG (FcγRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRβ can function as either a positive or negative regulator, leaving a mechanistic explanation...
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