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An estimated 20 million people died in the influenza pandemic of 1918. The 1918 virus also spread to swine and continues to cause swine influenza outbreaks. We report here the crystal structures of the haemagglutinins (HAs) of the 1918 virus, the first swine influenza virus of 1930, and the human virus of 1934. We also present structures of HAs complexed with receptor analogues that show how human...
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