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Human EFHC1 is a member of the EF-hand superfamily of Ca 2+ -binding proteins with three DM10 domains of unclear function. Point mutations in the EFHC1 gene are related to juvenile myoclonic epilepsy, a fairly common idiopathic generalized epilepsy. Here, we report the first structural and thermodynamic analyses of the EFHC1C-terminus (residues 403–640; named EFHC1C), comprising the last DM10...
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