Search results for: Jong Cheol Jeong

Items from 1 to 20 out of 36 results

article

Molecular incompatibility between pig CD200 and human CD200 receptor in in vitro xenogeneic immune responses

Bomin Kim, Ji‐Jing Yan, Tae Kyeom Kang, Wook‐Bin Lee, more

Xenotransplantation > 31 > 3 > n/a - n/a

Overexpression of human CD200 (hCD200) in porcine endothelial cells (PECs) has been reported to suppress xenogeneic immune responses of human macrophages against porcine endothelial cells. The current study aimed to address whether the above‐mentioned beneficial effect of hCD200 is mediated by overcoming the molecular incompatibility between porcine CD200 (pCD200) and hCD200 receptor or simply by...

article

The 2021 KDIGO blood pressure target and the progression of chronic kidney disease: Findings from KNOW‐CKD

Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, more

Journal of Internal Medicine > 294 > 5 > 653 - 664

Background The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline for the management of blood pressure (BP) in chronic kidney disease (CKD) recommends a target systolic BP of <120 mmHg as this target can provide cardiovascular benefits. However, it remains unclear whether implementing the new BP target could improve kidney outcomes. Methods The association between...

article

Ethical review of COVID‐19 vaccination requirements for transplant center staff and patients

Olivia S. Kates, Peter G. Stock, Michael G. Ison, Richard D. M. Allen, more

American Journal of Transplantation > 22 > 2 > 371 - 380

Transplant centers seeking to increase coronavirus disease 2019 (COVID‐19) vaccine coverage may consider requiring vaccination for healthcare workers or for candidates. The authors summarize current data to inform an ethical analysis of the harms, benefits, and individual and societal impact of mandatory vaccination, concluding that vaccine requirements for healthcare workers and transplant candidates...

article

The tacrolimus metabolism affect post‐transplant outcome mediating acute rejection and delayed graft function: analysis from Korean Organ Transplantation Registry data

Han Ro, Jong Cheol Jeong, Jin Min Kong, Ji Won Min, more

Transplant International > 34 > 1 > 163 - 174

Tacrolimus is a key drug in kidney transplantation (KT) with a narrow therapeutic index. The association between the tacrolimus metabolism rate and KT outcomes have not been investigated in large‐scale multi‐center studies. The Korean Organ Transplantation Registry (KOTRY) datasets were used. A total of 3456 KT recipients were analyzed. The tacrolimus metabolism rate was defined as blood trough concentration...

article

Peripheral blood transcriptome analysis and development of classification model for diagnosing antibody‐mediated rejection vs accommodation in ABO‐incompatible kidney transplant

Hee Jung Jeon, Jae‐Ghi Lee, Kwangsoo Kim, Joon Young Jang, more

American Journal of Transplantation > 20 > 1 > 112 - 124

The major obstacle to successful ABO blood group–incompatible kidney transplantation (ABOi KT) is antibody‐mediated rejection (AMR). This study aimed to investigate transcriptional profiles through RNA sequencing and develop a minimally invasive diagnostic tool for discrimination between accommodation and early acute AMR in ABOi KT. Twenty‐eight ABOi KT patients were selected: 18 with accommodation...

article

Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Wonsun Hwang, Mi Sook Cho, Ji Eun Oh, Ji Hyun Lee, more

Hemodialysis International > 22 > 4 > 507 - 514

Introduction: Malnutrition is prevalent in hemodialysis (HD) patients, and the risk of mortality is strongly correlated with malnutrition. Current methods of nutritional evaluation are mostly subjective, time‐consuming, and cumbersome. Creatinine index (CI) and geriatric nutritional risk index (GNRI) are very simple and objective methods to assess the nutritional status of HD patients. The present...

article

Effect of an oxygen‐generating scaffold on the viability and insulin secretion function of porcine neonatal pancreatic cell clusters

Eun Mi Lee, Ji‐In Jung, Zahid Alam, Hee‐Gyeong Yi, more

Xenotransplantation > 25 > 2 > n/a - n/a

Background Islet encapsulation techniques have shown limited success in maintaining islet survival and function because encapsulation decreases oxygen supply. In this study, an oxygen‐generating scaffold was fabricated to prevent hypoxic cell damage and improve the viability and insulin secretion of islets. Methods We fabricated an oxygen‐generating scaffold by mixing calcium peroxide (CaO₂) with...

article

VDJ gene usage among B-cell receptors in ABO-incompatible kidney transplantation determined by RNA-seq Transcriptomic analysis

Hee Jung Jeon, Kwangsoo Kim, Jae-Ghi Lee, Joon Young Jang, more

BMC Nephrology > 2017 > 18 > 1 > 1-11

Background Studies on B-cell subtypes and V(D)J gene usage of B-cell receptors in kidney transplants are scarce. This study aimed to investigate V(D)J gene segment usage in ABO-incompatible (ABOi) kidney transplant (KT) patients compared to that in ABO-compatible (ABOc) KT patients. Methods We selected 16 ABOi KT patients with accommodation (ABOiA), 6 ABOc stable KT patients (ABOcS), and 6 ABOi...

article

Clinical outcomes of ABO‐ and HLA‐incompatible kidney transplantation: a nationwide cohort study

Eun Jeong Ko, Ji Hyun Yu, Chul Woo Yang, Byung Ha Chung, more

Transplant International > 30 > 12 > 1215 - 1225

This was a nationwide cohort study to investigate the impact of anti‐A/B and donor‐specific anti‐HLA (HLA‐DSA) antibodies on the clinical outcomes in kidney transplant recipients (KTRs). We classified a total of 1964 KTRs into four groups: transplants from ABO‐incompatible donors (ABOi, n = 248); transplants in recipients with HLA‐DSA (HLAi, n = 144); transplants from combined ABOi and HLAi donors...

article

Poor predictability of QuantiFERON-TB assay in recipients and donors for tuberculosis development after kidney transplantation in an intermediate-TB-burden country

Enkthuya Jambaldorj, Miyeun Han, Jong Cheol Jeong, Tai Yeon Koo, more

BMC Nephrology > 2017 > 18 > 1 > 1-7

Background Tuberculosis (TB) is a common opportunistic infection after kidney transplantation (KT). The QuantiFERON-TB-Gold In-Tube test (QFT) is widely used for assessing latent TB; however, it is currently unclear whether the pre-KT QFT of the recipient and donor can predict post-KT TB. Methods We retrospectively reviewed patients who received KT between January 2009 and December 2015 at Seoul...

article

The molecular basis of breast cancer pathological phenotypes

Yujing J Heng, Susan C Lester, Gary MK Tse, Rachel E Factor, more

The Journal of Pathology > 241 > 3 > 375 - 391

The histopathological evaluation of morphological features in breast tumours provides prognostic information to guide therapy. Adjunct molecular analyses provide further diagnostic, prognostic and predictive information. However, there is limited knowledge of the molecular basis of morphological phenotypes in invasive breast cancer. This study integrated genomic, transcriptomic and protein data to...

article

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

Jlenia Guarnerio, Marco Bezzi, Jong Cheol Jeong, Stella V. Paffenholz, more

Cell > 2016 > 166 > 4 > 1055-1056

article

Outcomes of dialysis and the transplantation options for patients with diabetic end‐stage renal disease in Korea

Hee Jung Jeon, Tai Yeon Koo, Miyeun Han, Ha Jin Kim, more

Clinical Transplantation > 30 > 5 > 534 - 544

BackgroundThe best therapeutic option for diabetic end‐stage renal disease (DMESRD) has not been established among living donor kidney transplantation (LDKT), deceased donor kidney transplantation (DDKT), simultaneous pancreas and kidney transplantation (SPK), and dialysis. MethodsWe retrospectively analyzed the outcomes of DMESRD patients at two Korean centers from February 2000 to December 2011...

chapter

A New Feature Selection Method for Improving the Precision of Diagnosing Abnormal Protein Sequences by Support Vector Machine and Vectorization Method

Eun-Mi Kim, Jong-Cheol Jeong, Ho-Young Pae, Bae-Ho Lee

Lecture Notes in Computer Science > Adaptive and Natural Computing Algorithms > Biomedical Signal and Image Processing > 364-372

Pattern recognition and classification problems are most popular issue in machine learning, and it seem that they meet their second golden age with bioinformatics. However, the dataset of bioinformatics has several distinctive characteristics compared to the data set in classical pattern recognition and classification research area. One of the most difficulties using this theory in bioinformatics...

chapter

A New Approach for Finding an Optimal Solution and Regularization by Learning Dynamic Momentum

Eun-Mi Kim, Jong Cheol Jeong, Bae-Ho Lee

Lecture Notes in Computer Science > Artificial Intelligence and Soft Computing – ICAISC 2006 > Neural Networks and Their Applications > 29-36

Regularization and finding optimal solution for the classification problems are well known issue in the machine learning, but most of researches have been separately studied or considered as a same problem about these two issues. However, it is obvious that these approaches are not always possible because the evaluation of the performance in classification problems is mostly based on the data distribution...

article

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

Jlenia Guarnerio, Marco Bezzi, Jong Cheol Jeong, Stella V. Paffenholz, more

Cell > 2016 > 165 > 2 > 289-302

Chromosomal translocations encode oncogenic fusion proteins that have been proven to be causally involved in tumorigenesis. Our understanding of whether such genomic alterations also affect non-coding RNAs is limited, and their impact on circular RNAs (circRNAs) has not been explored. Here, we show that well-established cancer-associated chromosomal translocations give rise to fusion circRNAs (f-circRNA)...

article

Beneficial effects of the transgenic expression of human sTNF-αR-Fc and HO-1 on pig-to-mouse islet xenograft survival

Ji-Jing Yan, Hye-Jeong Yeom, Jong Cheol Jeong, Jae-Ghi Lee, more

Transplant Immunology > 2016 > 34 > C > 25-32

Both human soluble tumor necrosis factor-α receptor-Fc (sTNF-αR-Fc) and heme oxygenase-1 (HO-1) transgenic pigs have been generated previously for xenotransplantation. Here, we investigated whether overexpression of sTNF-αR-Fc or HO-1 in pig islets prolongs islet xenograft survival. Adult porcine islets were isolated from human sTNF-αR-Fc or HO-1 transgenic and wild type pigs, and were transplanted...

article

GOAL: the comprehensive gene ontology analysis layer

Jong Cheol Jeong, George Li, Xue-Wen Chen

Science China Information Sciences > 2016 > 59 > 7 > 1-8

Homogeneity or heterogeneity of cells is the most fundamental and important features of analyzing biological associations of genes and gene products. Recent bioinformatics technology requires an automated high-throughput analysis application that can handle massively produced data from next generation sequences and dramatically increased size of public proteomic/genomic databases. Although Gene ontology...

article

Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno‐immune response

Hwajung Kim, Wayne J. Hawthorne, Hee Jung Kang, Yoo Jin Lee, more

Xenotransplantation > 22 > 4 > 260 - 272

BackgroundWith the introduction of the α1, 3‐galactosyltransferase gene‐knockout (GT‐KO) pig and its pivotal role in preventing hyperacute rejection (HAR), coagulation remains a considerable obstacle yet to be overcome in order to provide long‐term xenograft survival. Thrombomodulin (TBM) plays a critical anticoagulant and anti‐inflammatory role in its part of the protein C pathway. Many studies have...

article

A New Semantic Functional Similarity over Gene Ontology

Jong Cheol Jeong, Xuewen Chen

IEEE/ACM Transactions on Computational Biology and Bioinformatics > 2015 > 12 > 2 > 322 - 334

Identifying functionally similar or closely related genes and gene products has significant impacts on biological and clinical studies as well as drug discovery. In this paper, we propose an effective and practically useful method measuring both gene and gene product similarity by integrating the topology of gene ontology, known functional domains and their functional annotations. Theproposed method...

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INFONA - science communication portal

Search results for: Jong Cheol Jeong

Molecular incompatibility between pig CD200 and human CD200 receptor in in vitro xenogeneic immune responses

The 2021 KDIGO blood pressure target and the progression of chronic kidney disease: Findings from KNOW‐CKD

Ethical review of COVID‐19 vaccination requirements for transplant center staff and patients

The tacrolimus metabolism affect post‐transplant outcome mediating acute rejection and delayed graft function: analysis from Korean Organ Transplantation Registry data

Peripheral blood transcriptome analysis and development of classification model for diagnosing antibody‐mediated rejection vs accommodation in ABO‐incompatible kidney transplant

Comparison of creatinine index and geriatric nutritional risk index for nutritional evaluation of patients with hemodialysis

Effect of an oxygen‐generating scaffold on the viability and insulin secretion function of porcine neonatal pancreatic cell clusters

VDJ gene usage among B-cell receptors in ABO-incompatible kidney transplantation determined by RNA-seq Transcriptomic analysis

Clinical outcomes of ABO‐ and HLA‐incompatible kidney transplantation: a nationwide cohort study

Poor predictability of QuantiFERON-TB assay in recipients and donors for tuberculosis development after kidney transplantation in an intermediate-TB-burden country

The molecular basis of breast cancer pathological phenotypes

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

Outcomes of dialysis and the transplantation options for patients with diabetic end‐stage renal disease in Korea

A New Feature Selection Method for Improving the Precision of Diagnosing Abnormal Protein Sequences by Support Vector Machine and Vectorization Method

A New Approach for Finding an Optimal Solution and Regularization by Learning Dynamic Momentum

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

Beneficial effects of the transgenic expression of human sTNF-αR-Fc and HO-1 on pig-to-mouse islet xenograft survival

GOAL: the comprehensive gene ontology analysis layer

Human thrombomodulin regulates complement activation as well as the coagulation cascade in xeno‐immune response

A New Semantic Functional Similarity over Gene Ontology

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