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Aggregation and misfolding of the amyloid beta (Aβ) peptide is thought to initiate Alzheimer’s disease (AD). Here we study the role played by its central segment (Aβ 18–35 ) in determining these properties. Aβ 18–35 has a solubility of 18μM. The soluble fraction consists mainly of small oligomers, which have mixed β-sheet and random coil structures. The monomer is mostly a random coil...
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