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Evidence has emerged supporting a link between high glycaemic index (GI) diets and type 2 diabetes (T2D). The aim of this study was to determine if dietary GI influences the development of hyperglycaemia in C57BL/6 mice to more closely reflect T2D. Male C57BL/6 mice (n=30) were randomly divided into 3 dietary groups consisting of either standard rodent chow (4.8 % fat, 20 % protein), or a high fat...
Stimulation of dopamine D2 receptors inhibits melanotrope pro-opiomelanocortin (POMC) biosynthesis and α-melanocyte-stimulating hormone (MSH) secretion. These effects are mediated by G-protein αi- and αo- subunits and are reversed by stimulating receptors linked to activation of Gαs protein. Melanotrope activity is increased by haloperidol, a D2 receptor antagonist, and decreased by bromocriptine,...
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