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Glycation on lysine side chains of recombinant monoclonal antibodies (mAb) is a well‐known phenomenon in manufacturing processes of biopharmaceuticals that potentially alter the efficacy of the therapeutic protein. In the present study, we report kinetic studies of glycation formation of the model protein Adalimumab, relative to glucose and non‐glycated protein in six Chinese hamster ovary (CHO) fed...
Post‐translational, nonenzymatic glycation of monoclonal antibodies (mAbs) in the presence of reducing sugars (in bioprocesses) is a widely known phenomenon, which affects protein heterogeneity and potentially has an impact on quality, safety, and efficacy of the end product. Quantification of individual glycation levels is compulsory for each mAb therapeutically applied in humans. We therefore propose...
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