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Cocaine dependence is a substantial public health problem, yet there are no clearly effective medication treatments. Amphetamine and topiramate have both shown promise for the treatment of cocaine dependence in preclinical and early-stage clinical studies. Eighty-one cocaine-dependent adults were randomized to receive a combination of extended-release mixed amphetamine salts (MAS-ER) and topiramate...
Aims There are no studies directly comparing self‐administration of methamphetamine and d‐amphetamine by humans. This study compared intranasal methamphetamine‐ and d‐amphetamine self‐administration and characterized the mood, performance and physiological effects produced by the drugs.
Design A randomized, double‐blind, placebo‐controlled, cross‐over study.
Setting An out‐patient research unit...
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