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Background & aims
miR‐21‐5p is a potent oncogenic microRNA targeting many key tumour suppressors including phosphatase and tensin homolog (PTEN). We recently identified PTEN as a key factor modulated by hepatitis C virus (HCV) to promote virion egress. In hepatocytes, expression of HCV‐3a core protein was sufficient to downregulate PTEN and to trigger lipid droplet accumulation. Here, we investigated...
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