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The present studies examined the relationship between the blockade of central α 1 -adrenoceptors, as measured by ex vivo binding of [ 3 H]prazosin in the cerebral cortex and the inhibition of behavioral activation to a mildly novel environment (cage change). It was found that intraventricular (i.v.t.) terazosin, a saline-soluble α 1 -adrenoceptor antagonist, dose dependently...
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