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Inflammation plays a critical role in the pathophysiology of acute myocardial infarction (AMI). Tumor necrosis factor-α (TNFα), a pleotropic cytokine, is an inflammatory trigger in several cell systems. To determine if myocyte cell death is associated with TNFα release in vivo, we monitored the alterations in plasma TNFα levels in 22 patients with AMI (Killip class I-II), 20 patients with AMI (Killip...
Chlamydia pneumonias infection is associated with atherosclerosis by serologic studies and detection of bacterial antigen within plaque. We sought to evaluate a possible etiologic role in an animal model.Thirty New Zealand white rabbits were given 3 separate intranasal inoculations of either C. pneumoniae (N = 20) or saline (N = 10) at 3 week intervals and fed chow enriched with a small (0.25%) amount...
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