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To investigate the effects of P, medroxyprogesterone acetate (MPA), and dydrogesterone (DYD) and its metabolite, 20-α-dihydrodydrogesterone (DHD) on endothelial synthesis of nitric oxide (NO) and characterize the signaling events recruited by these compounds. The Women’s Health Initiative trial reports an excess of heart disease in postmenopausal women receiving MPA. Cell culture. Research laboratory...
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